HCID 22349875, compound → 2-tert-Butyl-4-{4-[3-(4-methyl-5-methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-propyl]-piperazin-1-yl}-6-difluoromethyl-pyrimidine hydrochloride

HRID 896226Notes

Reaction equation

HRID 896226 reaction equation
[CH3:1][N:2]1[C:6]([CH3:7])=[N:5][N:4]=[C:3]1[SH:8].[C:9]([C:13]1[N:18]=[C:17]([N:19]2[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][CH2:27][Cl:28])[CH2:21][CH2:20]2)[CH:16]=[C:15]([CH:29]([F:31])[F:30])[N:14]=1)([CH3:12])([CH3:11])[CH3:10]>>[ClH:28].[C:9]([C:13]1[N:18]=[C:17]([N:19]2[CH2:20][CH2:21][N:22]([CH2:25][CH2:26][CH2:27][S:8][C:3]3[N:2]([CH3:1])[C:6]([CH3:7])=[N:5][N:4]=3)[CH2:23][CH2:24]2)[CH:16]=[C:15]([CH:29]([F:30])[F:31])[N:14]=1)([CH3:10])([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 22349875HCID 22349875, compoundHCID 178434152HCID 178434152, compound

Product 1

HCID 223498622-tert-Butyl-4-{4-[3-(4-methyl-5-methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-propyl]-piperazin-1-yl}-6-difluoromethyl-pyrimidine hydrochlorideYield 31.5%

Procedure

0.5 g of 4-methyl-5-methyl-4H-[1,2,4]triazole-3-thiol (3.87 mmol) were reacted with 1.34 g of 2-tert-butyl-4-[4-(3-chloro-propyl)-piperazin-1-yl]-6-difluoromethyl-pyrimidine (3.87 mmol) to yield 0.58 g of the title compound.

Sources & evidence

ORD record
ord-9bfebc95fffd4edfaf3a4c5d3d591e03
Source dataset
uspto-grants-2005_07
Patent number
US06919342B2

Reaction notes

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