HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 22349981, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | (Trimethylsilyl)imidazole | HCID 28925 | — |
| Reactant | 4,6-Dichloro-2-[2-(3-chlorophenyl)ethyl]pyrimidine | HCID 22349988 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 22349981 | HCID 22349981 | 62.7% |
Reaction Steps
A solution of 2-(3-chlorophenethyl)-4,6-dichloropyrimidine (286 mg, 1 mmol) 91 in 3 mL of dry DMF was treated with 1-trimethylsilylimidazole (140 mg, 1 mmol) and CsF (152 mg, 1 mmol) at RT overnight. Aqueous work up and chromatography (silica gel, hexane:ethyl acetate, 1:1) gave 200 mg of 4-chloro-2-(3-chlorophenethyl)-6-(1-imidazolyl)pyrimidine (92).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919347B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-d9b23acd093448ae9e4dfab5e50c9c62 |
| Source note | uspto-grants-2005_07 |