反应详情

2-nitro-4-((1-tert-butyloxycarbonylpiperidin-4-yl)methoxy)-5-methoxybenzonitrile (1.17 g, 3 mmol) in CH2Cl2 (12 ml) was treated with TFA (2.4 ml) for 1 hour at room temperature. The solvent was evaporated, the residue was taken up in a mixture of CH2Cl2 and concentrated sodium bicarbonate, extracted with CH2Cl2. The organic phase was dried over MgSO4, concentrated to give title compound as a solid (770 mg, 88%).

1. customThe solvent was evaporated
2. additionthe residue was taken up in a mixture of CH2Cl2 and concentrated sodium bicarbonate
3. extractionextracted with CH2Cl2
4. dry with materialThe organic phase was dried over MgSO4
5. concentrationconcentrated