反应详情

3-methoxy-4-benzyloxybenzonitrile (4.78 g, 20 mmol) in acetic acid (10 ml) was slowly added to nitric acid (d=1.42, 25 ml) at 20-30° with cooling in an ice bath. The mixture was then stirred at room temperature for 6 hours. The reaction mixture was treated with potassium hydroxyde (10N) at 0° C. The basic mixture (pH 10) was extracted with CH2Cl2, the organic phase was dried over MgSO4, concentrated to give title compound (3.62 g, 64%).

1. temperaturewith cooling in an ice bath
2. extractionThe basic mixture (pH 10) was extracted with CH2Cl2
3. dry with materialthe organic phase was dried over MgSO4
4. concentrationconcentrated