HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → N'-(2-cyano-4-methoxy-5-benzyloxyphenyl)-N,N-dimethylimidoformamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 2-Amino-4-(benzyloxy)-5-methoxybenzonitrile | HCID 11701584 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N'-(2-cyano-4-methoxy-5-benzyloxyphenyl)-N,N-dimethylimidoformamide | HCID 11609261 | — |
Reaction Steps
2-amino-4-benzyloxy-5-methoxy benzonitrile (102 g, 400 mmol) in toluene (1.51) was reacted with DMF-DMA (110 ml, 780 mmol) at reflux for 5 hours. The solvent was evaporated, the residue triturated with ether to give title compound as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919338B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-395d8c12acfd43f092278532e885aad7 |
| Source note | uspto-grants-2005_07 |