HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl N,N-dipropan-2-ylcarbamimidate → N-(2-tert-butoxyethyl)-3-chloro-4-fluoroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl N,N-dipropan-2-ylcarbamimidate | HCID 22010542 | — |
| Reactant | N-2-hydroxyethyl-3-chloro-4-fluoroaniline | HCID 22349678 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-tert-butoxyethyl)-3-chloro-4-fluoroaniline | HCID 22349667 | 60% |
Reaction Steps
N-2-hydroxyethyl-3-chloro-4-fluoroaniline (1.48 g, 7.81 mmol) in CH2Cl2 (20 ml) was reacted with N,N-diisopropyl O-tert-butyl-isourea (6.25 g, 31.2 mmol) at room temperature over night. The product was purified by silicagel chromatography, Eluant, ether/petroleum ether 5/95, 10/90 to give title compound (1.15 g, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919338B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-da7c244e2963435497e4d1643dda372e |
| Source note | uspto-grants-2005_07 |