HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 11676009, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trityl chloride | HCID 6456 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2-Amino-thiazol-5-yl)-acetic acid methyl ester | HCID 963498 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11676009 | HCID 11676009 | 91.9% |
Reaction Steps
Methyl-(2-amino-1,3-thiazole-5-yl)acetate (1 g, 5.8 mmol) in CH2Cl2 (15 ml) was reacted with triphenylmethyl chloride (1.73 g, 6.2 mmol) and triethylamine (0.89 ml, 6.4 mmol) at 0° C. for 1.5 hour. Water was added to the mixture which was extracted with ethyl acetate, dried, purified by silica gel chromatography to give title compound (2.21 g, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919338B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-aa23029c7ee6469980a3c9172cec0a85 |
| Source note | uspto-grants-2005_07 |