Piperidine → HCID 86589732, compound

Participants

Reaction Steps

N′-(2-cyano-4-methoxy-5-(3-chloropropoxy)4-methoxyphenyl)-N,N-dimethylimidoformamide (3 g, 10 mmol) in acetonitrile (50 ml) was reacted with piperidine (10 ml, 100 mmol) in presence of KI (300 mg, 1.8 mmol) and K2CO3 (2.1 g, 0.015 mmol) at 75° C. under argon for 3 hours. The solvent was evaporated, and the residue purified by silica gel chromatography, Eluant CH2Cl2/MeOH, NH3 3N 95/5 to give title compound (3.48 g, 100%).

Provenance & Evidence