Cyclopropylamine → 1-[5-Cyclopropylaminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one

HRID 896308Notes

Reaction equation

[CH3:1][NH:2][CH2:3][C:4]1[CH:31]=[CH:30][C:7]2[N:8]([CH2:25][CH2:26][CH:27]([CH3:29])[CH3:28])[C:9]([CH2:11][N:12]3[C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=4[N:14]([CH:21]([CH3:23])[CH3:22])[C:13]3=[O:24])=[N:10][C:6]=2[CH:5]=1.[CH:32]1(N)C[CH2:33]1>>[CH:1]1([NH:2][CH2:3][C:4]2[CH:31]=[CH:30][C:7]3[N:8]([CH2:25][CH2:26][CH:27]([CH3:29])[CH3:28])[C:9]([CH2:11][N:12]4[C:16]5[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=5[N:14]([CH:21]([CH3:23])[CH3:22])[C:13]4=[O:24])=[N:10][C:6]=3[CH:5]=2)[CH2:33][CH2:32]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 208139711-[5-methylaminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one

Product 1

HCID 208140001-[5-Cyclopropylaminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one

Procedure

1-[5-Cyclopropylaminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one was prepared by the same procedure as 1-[5-methylaminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one, except using cyclopropylamine.

Sources & evidence

ORD record: ord-4ae3eab496da4bb4a8b7771b074de81a
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06919331B2

Reaction notes

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