Potassium Cyanide → HCID 22349407, compound

Participants

Reaction Steps

A mixture of methanesulfonic acid 2-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl ester (16 mg, 0.033 mmol) and KCN (21 mg, 0.33 mmol) in DMF was stirred for 24 h at ambient temperature. The solvent was evaporated and the residue was purified by prep-HPLC (gradient 10%-100% B) to give 12 mg (88%) of [2-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-5-yl]-acetonitrile as a colorless gum.

Provenance & Evidence