1-[5-aminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one → 1-[5-(2-Amino-ethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one

HRID 896310Notes

Reaction equation

HRID 896310 reaction equation
NCC1C=CC2N(CCC(C)C)C(CN3C4C=CC=CC=4N(C(C)C)C3=O)=NC=2C=1.[CH:31]([N:34]1[C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=2[N:36]([CH2:43][C:44]2[N:48]([CH2:49][CH2:50][CH:51]([CH3:53])[CH3:52])[C:47]3[CH:54]=[CH:55][C:56]([CH2:58][C:59]#[N:60])=[CH:57][C:46]=3[N:45]=2)[C:35]1=[O:61])([CH3:33])[CH3:32]>>[NH2:60][CH2:59][CH2:58][C:56]1[CH:55]=[CH:54][C:47]2[N:48]([CH2:49][CH2:50][CH:51]([CH3:53])[CH3:52])[C:44]([CH2:43][N:36]3[C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=4[N:34]([CH:31]([CH3:33])[CH3:32])[C:35]3=[O:61])=[N:45][C:46]=2[CH:57]=1

Participants

3

Reactant 2

HCID 116758201-[5-aminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-oneHCID 22349407HCID 22349407, compound

Product 1

HCID 208139841-[5-(2-Amino-ethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one

Procedure

1-[5-(2-Amino-ethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one was prepared by the same procedure as 1-[5-aminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one, except using [2-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-5-yl]-acetonitrile.

Sources & evidence

ORD record
ord-e8cc23f4f7e7485cbe6f43baeb1c4d3c
Source dataset
uspto-grants-2005_07
Patent number
US06919331B2

Reaction notes

Loading…