HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 22349332, compound → 1-(3-methyl-butyl)-2-(2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1H-benzoimidazole-5-carboxamidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 22349332 | HCID 22349332 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | 1-(3-methyl-butyl)-2-(2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1H-benzoimidazole-5-carboxamidine | HCID 22349371 | 99% |
Reaction Steps
2-(3-Isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxamidine (20 mg, 0.05 mmol) was dissolved in 30% TFA/CH2Cl2 and stirred at reflux for 1 h. The solvent was removed and the residues triturated with ether to give 18 mg (99%) of 1-(3-methyl-butyl)-2-(2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1H-benzoimidazole-5-carboxamidine as a white solid as the TFA salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919331B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-2f30c623f7934d52a3392ce6af17fd41 |
| Source note | uspto-grants-2005_07 |