反应详情

A solution of {3-[5-(N-hydroxycarbamimidoyl)-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-2-oxo-2,3-dihydro-benzoimidazol-1-yl}-acetic acid tert-butyl ester (1.4 g, 2.76 mmol) in AcOH (50 ml) was added to 10% Pd/C (166 mg) and hydrogenated at 50 psi for 4 h then the mixture was filtered and washed with MeOH. The solvent was removed and the residue triturated with EtOAc to give 1 g (74%) of {3-[5-carbamimidoyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-2-oxo-2,3-dihydro-benzoimidazol-1-yl}-acetic acid tert-butyl ester as a white solid.

1. filtrationthe mixture was filtered
2. washwashed with MeOH
3. customThe solvent was removed
4. customthe residue triturated with EtOAc