2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline → HCID 22349282, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-amino-4-(3-hydroxy-propylamino)-benzonitrile (484 mg, 2.53 mmol) and (3-isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-acetic acid (646 mg, 2.78 mmol) in THF (50 ml) was treated with EEDQ (625 mg, 2.53 mmol) and stirred for 48 h at 23° C. A grey precipitate was filtered off to give 526 mg (47%) of N-[5-Cyano-2-(3-hydroxy-propylamino)-phenyl]-2-(3-isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-acetamide.

Provenance & Evidence