{3-[5-carbamimidoyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-2-oxo-2,3-dihydro-benzoimidazol-1-yl}-acetic acid tert-butyl ester → 1-[5-Carbamimidoyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-1H-benzotriazole-5-carboxamidine

HRID 896326Notes

Reaction equation

C(OC(=O)CN1C2C=CC=CC=2N(CC2N(CCC(C)C)C3C=CC(C(=N)N)=CC=3N=2)C1=O)(C)(C)C.O[NH:38][C:39]([C:41]1[CH:68]=[CH:67][C:44]2[N:45]([CH2:48][C:49]3[N:53]([CH2:54][CH2:55][CH:56]([CH3:58])[CH3:57])[C:52]4[CH:59]=[CH:60][C:61]([C:63](=[NH:66])[NH:64]O)=[CH:62][C:51]=4[N:50]=3)[N:46]=[N:47][C:43]=2[CH:42]=1)=[NH:40]>>[C:63]([C:61]1[CH:60]=[CH:59][C:52]2[N:53]([CH2:54][CH2:55][CH:56]([CH3:57])[CH3:58])[C:49]([CH2:48][N:45]3[C:44]4[CH:67]=[CH:68][C:41]([C:39]([NH2:40])=[NH:38])=[CH:42][C:43]=4[N:47]=[N:46]3)=[N:50][C:51]=2[CH:62]=1)(=[NH:64])[NH2:66]

Participants

Reactant 2

HCID 20814118{3-[5-carbamimidoyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-2-oxo-2,3-dihydro-benzoimidazol-1-yl}-acetic acid tert-butyl ester

HCID 178446112HCID 178446112, compound

Product 1

HCID 208139861-[5-Carbamimidoyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-1H-benzotriazole-5-carboxamidine

Procedure

1-[5-Carbamimidoyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-1H-benzotriazole-5-carboxamidine was prepared as described for {3-[5-carbamimidoyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-2-oxo-2,3-dihydro-benzoimidazol-1-yl}-acetic acid tert-butyl ester using N-hydroxy-1-[5-(N-hydroxycarbamimidoyl)-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-1H-benzotriazole-5-carboxamidine.

Sources & evidence

ORD record: ord-647738d52a5843d8bbf5035f508e1975
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06919331B2

Reaction notes

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