HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[5-(benzhydrylidene-amino)-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one → 1-[5-amino-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[5-(benzhydrylidene-amino)-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one | HCID 86590115 | — |
| Solvent | HCl tetrahydrofuran | HCID 18422008 | — |
| Product | 1-[5-amino-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one | HCID 20813987 | 85.1% |
Reaction Steps
A solution of 1-[5-(benzhydrylidene-amino)-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one (32 mg, 0.06 mmol) in 0.5 M HCl-THF was stirred at ambient temperature for 1 h. The solvent was evaporated and the residue purified by prep-HPLC (gradient 10%-100% B) to give 20 mg (85%) of 1-[5-amino-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-3-isopropyl-1,3-dihydro-benzoimidazol-2-one as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919331B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-e439695ebeba47b198adeab96bb92e31 |
| Source note | uspto-grants-2005_07 |