反应详情

3-[5-Cyano-1-(3-methyl-butyl)-1H-benzoimidazol-2-ylmethyl]-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid ethyl ester was prepared by the same procedure as 2-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carbonitrile, except using 2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid ethyl ester (N. Meanwell et al, J. Org. Chem, 1995, 60(6), 1565-82) and was used without purification in the next reaction.

1. customwas used without purification in the next reaction