HCID 22349403, compound → HCID 22349339, compound

Participants

Reaction Steps

To a solution 2-benzyloxymethyl-1-(3-methyl-butyl)-1H-benzoimidazole-5-carbonitrile (1.12 g, 3.36 mmol) in methanol (50 mL) and concentrated HCl (2.5 mL) was added 10% Pd/C (120 mg). This mixture was rocked under a hydrogen atmosphere in a Parr shaker(45 psi) for 48 hrs. The catalyst was removed by filtration and the solution concentrated in vacuo to give [5-aminomethyl-1-(3-methyl-butyl)-1H-benzoimidazol-2-yl]-methanol (1.14 g, 100%) as a tan solid. A small portion was purified by prep HPLC (30-100% B) to give C-[2-Benzyloxymethyl-1-(3-methyl-butyl)-1H-benzoimidazol-5-yl]-methylamine; HCl salt:

Provenance & Evidence