HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → 3-cyclopropyl-1H-quinazoline-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | (2-Cyclopropylcarbamoyl-phenyl)-carbamic acid methyl ester | HCID 20814106 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-cyclopropyl-1H-quinazoline-2,4-dione | HCID 17221449 | 53% |
Reaction Steps
A solution of (2-cyclopropylcarbamoyl-phenyl)-carbamic acid methyl ester was dissolved in MeOH (100 ml) and treated with NaOMe (0.5 M, 5 ml, 2.5 mmol) and the mixture heated to reflux for 12 h. The mixture was cooled and filtered to give 4.05 g (53%) of 3-cyclopropyl-1H-quinazoline-2,4-dione as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919331B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-3790d333a5eb4b9c9f33ac2782c1edb4 |
| Source note | uspto-grants-2005_07 |