Pivaloyl chloride → HCID 69708999, compound

Participants

Reaction Steps

A solution of 4-(4-hydroxy-butylamino)-3-nitro-benzonitrile (10.0 g, 42.5 mmol) in pyridine (100 mL) was cooled to 0° C. under nitrogen. Pivaloyl chloride (5.8 mL, 47 mmol) was dropwise added and the resulting solution allowed to warm to room temperature and stirred overnight. The solvent was removed in vacuo and the residue stripped with toluene. The residue was suspended in ethyl acetate, filtered, and the filtrated concentrated to give 2,2-dimethyl-propionic acid 4-(4-cyano-2-nitro-phenylamino)-butyl ester (13.3 g, 98%) as a yellow solid.

Provenance & Evidence