Hydrochloric Acid → HCID 69804566, compound

Participants

Reaction Steps

A solution of 2,2-dimethyl-propionic acid 4-{5-(tert-butoxycarbonylamino-methyl)-2-[2,4-dioxo-3-(2,2,2-trifluoro-ethyl)-3,4-dihydro-2H-quinazolin-1-ylmethyl]-benzoimidazol-1-yl}-butyl ester (59 mg, 0.089 mmol) and TFA (138 μL, 1.79 mmol) in dichloromethane (2 mL) was stirred for 4 hrs at room temperature. The volatiles were removed in vacuo and the residue dissolved in dichloromethane. A solution of 4N HCl in dioxane (233 μL, 10 equiv.) was added, followed by concentration. The residue was triturated from diethyl ether and filtered to give the title compound (46 mg, 87%) as a tan solid:

Provenance & Evidence