Hydrochloric Acid → HCID 69753219, compound

Participants

Reaction Steps

A solution of acetic acid 4-{5-(tert-butoxycarbonylamino-methyl)-2-[2,4-dioxo-3-(2,2,2-trifluoro-ethyl)-3,4-dihydro-2H-quinazolin-1-ylmethyl]-benzoimidazol-1-yl}-butyl ester (98 mg, 0.16 mmol) and TFA (244 μL, 3.17 mmol) in dichloromethane (3 mL) was stirred for 4 hrs at room temperature. The volatiles were removed in vacuo and the residue dissolved in dichloromethane. A solution of 4N HCl in dioxane (0.4 mL, 10 equiv.) was added, followed by concentration. The residue was triturated from diethyl ether and filtered to give acetic acid 4-{5-aminomethyl-2-[2,4-dioxo-3-(2,2,2-trifluoro-ethyl)-3,4-dihydro-2H-quinazolin-1-ylmethyl]-benzoimidazol-1-yl }-butyl ester; HCl salt (53 mg, 60%) as a white solid:

Provenance & Evidence