[1-(4-hydroxy-butyl)-2-(3-vinyl-indazol-1-ylmethyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester → [2-(3-ethyl-indazol-1-ylmethyl)-1-(4-hydroxy-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester

Participants

Reaction Steps

To a solution of [1-(4-hydroxy-butyl)-2-(3-vinyl-indazol-1-ylmethyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester (115 mg, 0.24 mmol) in methanol (35 mL) was added 10% Pd/C (12 mg) and this suspension was rocked in a Parr shaker under a hydrogen atmosphere (45 psi) for 2 hrs. The catalyst was removed by filtration and the filtrate concentrated in vacuo to yield [2-(3-ethyl-indazol-1-ylmethyl)-1-(4-hydroxy-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester (106 mg, 92%) as a white foam:

Provenance & Evidence