Hydrochloric Acid → HCID 20813988, compound

Participants

Reaction Steps

To a solution of [2-[2,4-dioxo-3-(2,2,2-trifluoro-ethyl)-3,4-dihydro-2H-quinazolin-1-ylmethyl]-1-(3-methanesulfonyl-propyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester (40 mg, 0.064 mmol) was added HCl (5 ml, 4.0 M in dioxane) and the mixture stirred for 12 h. The solvent was removed to give a white solid. The solid was purified by preparative HPLC to give 16.6 mg (40%) of 1-[5-aminomethyl-1-(3-methanesulfonyl-propyl)-1H-benzoimidazol-2-ylmethyl]-3-(2,2,2-trifluoro-ethyl)-1H-quinazoline-2,4-dione as a white powder.

Provenance & Evidence