HCID 69719549, compound → HCID 22349367, compound

Participants

Reaction Steps

To a solution of acetic acid 5-cyano-1-(4-fluoro-butyl)-1H-benzoimidazol-2-ylmethyl ester (1.3 g, 4.5 mmol) in MeOH (50 ml), EtOH (10 ml), concentrated HCl (10 ml) and 10% Pd/C (100 mg) was hydrogenated for 2 h. The solution was filtered and concentrated. The residue was dissolved in EtOAc and washed with aq NaHCO3. The product remains in the aqueous layer. The water was removed and the residue washed with hot EtOAc. The EtOAc extracts are concentrated to give 0.32 g (18%) of [5-aminomethyl-1-(4-fluoro-butyl)-1H-benzoimidazol-2-yl]-methanol as a white solid.

Provenance & Evidence