Methyl 2-amino-3-nitrobenzoate → 2,3-Diaminobenzoic acid methyl ester

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A mixture of 2-amino-3-nitro-benzoic acid methyl ester (8.0 g, 40.8 mmol) with 10% Pd/C (800 mg) in THF (60 mL) and methanol (60 mL) was rocked under a hydrogen atmosphere (45 psi) for 45 min. Fitration and concentration afforded 2,3-diamino-benzoic acid methyl ester as a tan solid, that was used without further purification. 2-Acetoxymethyl-1H-benzoimidazole-4-carboxylic Acid Methyl Ester

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