反应详情

Dissolve the compound obtained in Example 1 (6.7 g) in a dioxane/absolute ethanol mixture (100 ml/20 ml) and add palladium-on-carbon (0.5 g). Stir magnetically at ambient temperature under a hydrogen atmosphere for 76 hours. Remove the palladium-on-carbon by filtration and remove the mixture of solvents by evaporation under reduced pressure. Crystallise the resulting oil by trituration in isopropyl ether. Recrystallise the resulting precipitate from a 9/1 cyclohexane/toluene mixture.

1. customRemove the palladium-on-carbon
2. filtrationby filtration
3. customremove
4. additionthe mixture of solvents
5. customby evaporation under reduced pressure
6. customCrystallise the resulting oil by trituration in isopropyl ether
7. customRecrystallise the resulting precipitate from a 9/1 cyclohexane/toluene mixture