Potassium Hydroxide → HCID 10272377, compound

HRID 896486Notes

Reaction equation

HRID 896486 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][O:9][C:10]2[CH:25]=[CH:24][C:13]([CH2:14][CH:15]([C:20]([O:22]C)=[O:21])[C:16]([O:18][CH3:19])=[O:17])=[CH:12][CH:11]=2)[C:5]2[CH:26]=[CH:27][CH:28]=[CH:29][C:4]=2[S:3]1.[OH-].[K+]>CO>[CH3:19][O:18][C:16](=[O:17])[CH:15]([CH2:14][C:13]1[CH:24]=[CH:25][C:10]([O:9][CH2:8][CH2:7][N:6]2[C:5]3[CH:26]=[CH:27][CH:28]=[CH:29][C:4]=3[S:3][C:2]2=[O:1])=[CH:11][CH:12]=1)[C:20]([OH:22])=[O:21]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 22351114HCID 22351114, compound

Product 1

HCID 10272377HCID 10272377, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Dissolve the compound obtained in Example 8 (0.5 g) in methanol (30 ml) and add potassium hydroxide (0.07 g) that has previously been dissolved in methanol. Leave for one week at ambient temperature with magnetic stirring. Remove the methanol by evaporation under reduced pressure and acidify the resulting residue with a 6N hydrochloric acid solution until a pH of 1 is obtained. Extract twice with 30 ml of ether each time and then evaporate the organic phase under reduced pressure after having dried it over magnesium sulphate. Precipitate the resulting residue in ether and filter off the precipitate which forms.

Workup

  1. customLeave for one week at ambient temperature with magnetic stirring
  2. customRemove the methanol
  3. customby evaporation under reduced pressure
  4. customis obtained
  5. extractionExtract twice with 30 ml of ether each time
  6. customevaporate the organic phase under reduced pressure
  7. dry with materialafter having dried it over magnesium sulphate
  8. filtrationPrecipitate the resulting residue in ether and filter off the precipitate which

Sources & evidence

ORD record
ord-9913c2ba1bd84069a4e8d30b103feeff
Source dataset
uspto-grants-2005_07
Patent number
US06919362B2

Reaction notes

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