Pyridine → HCID 85451249, compound

HRID 896491Notes

Reaction equation

HRID 896491 reaction equation
[C:1]([C:9]1[CH:37]=[CH:36][C:12]2[N:13]([CH2:17][CH2:18][O:19][C:20]3[CH:35]=[CH:34][C:23]([CH2:24][CH:25]([C:30]([O:32][CH3:33])=[O:31])[C:26]([O:28][CH3:29])=[O:27])=[CH:22][CH:21]=3)[C:14](=[O:16])[S:15][C:11]=2[CH:10]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:38][O:39][NH2:40].N1C=CC=CC=1>CO.O>[CH3:38][O:39][N:40]=[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:9]1[CH:37]=[CH:36][C:12]2[N:13]([CH2:17][CH2:18][O:19][C:20]3[CH:21]=[CH:22][C:23]([CH2:24][CH:25]([C:30]([O:32][CH3:33])=[O:31])[C:26]([O:28][CH3:29])=[O:27])=[CH:34][CH:35]=3)[C:14](=[O:16])[S:15][C:11]=2[CH:10]=1

Participants

6

Reactant 3

HCID 1049PyridineHCID 4113O-MethylhydroxylamineHCID 9958279S26948

Product 1

HCID 85451249HCID 85451249, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

The compound obtained in Example 18 is dissolved in a minimum of methanol and then 4 equivalents of O-methylhydroxylamine, previously dissolved in a few milliliters of water, and 4.5 equivalents of pyridine are added in succession. The reaction mixture is heated at reflux for 24 hours and then hydrolysed in water and filtered; the resulting precipitate is recrystallised from methanol.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 24 hours
  3. filtrationhydrolysed in water and filtered
  4. customthe resulting precipitate is recrystallised from methanol

Sources & evidence

ORD record
ord-bc2ff781fa324fb5bb5ca842b7502f8f
Source dataset
uspto-grants-2005_07
Patent number
US06919362B2

Reaction notes

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