Water → HCID 22351063, compound

Participants

Reaction Steps

The compound obtained in Example 30 (274 mg) is dissolved in 5 ml of methanol, 2.5 ml of THF and 5 ml of water. A 2M solution of sodium hydroxide is added (1.8 ml) and the reaction mixture is stirred for 4 days at ambient temperature. The solvents are then evaporated off under reduced pressure, and the resulting residue is taken up in water and extracted with ethyl acetate. The aqueous phase is cooled to 0° C. and acidified with a 2M hydrochloric acid solution, and the resulting solid is filtered off.

Provenance & Evidence