Water → HCID 86759786, compound

Participants

Reaction Steps

5-Methyl-3-naphthylcarbonyl-5-phenylimidazolidine-2,4-dione (800 mg) was dissolved in DMF (8 mL) and tert-butyl bromoacetate (452 mg) was added. Potassium carbonate (336 mg) was further added, and the mixture was stirred at room temperature overnight. After water was added carefully to the reaction solution, ethyl acetate (200 mL) was added, followed by extraction. The resulting organic layer was washed with 1N hydrochloric acid, an aqueous saturated sodium bicarbonate solution and a saturated brine in turn, and dried over anhydrous magnesium sulfate, and the solvent was distilled off. Further recrystallization with IPE afforded 704 mg of white crystals.

Provenance & Evidence