Hydrochloric Acid → HCID 22351163, compound

Participants

Reaction Steps

Tert-butyl (5-methyl-3-naphthylcarbonyl-2,4-dioxo-5-phenylimidazolidinyl acetate (400 mg) was dissolved in a 20% trifluoroacetic acid/dichloromethane solution (10 mL), and the mixture was stirred at room temperature overnight. After 0.5N hydrochloric acid was added, and the solution was extracted twice using chloroform (100 mL). The resulting organic layer was washed with a saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was distilled off. Further recrystallization from IPE afforded 276 mg of white crystals.

Provenance & Evidence