Dimethylhydantoin → HCID 12112018, compound

Participants

Reaction Steps

5,5-Dimethylimidazolidine-2,4-dione (1.28 g) was dissolved in tetrahydrofuran (50 mL), and sodium hydride (60%, in oil) (0.80 g) was added at 0° C. under ice-cooling. After stirred for 30 minutes, 1-naphthoyl chloride (3.80 g) was added at 0° C., and the mixture was stirred at room temperature overnight. Ethyl acetate (200 mL) was added to the reaction solution, the mixture was washed with a saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was distilled off. Further purification by silica gel chromatography (hexane:ethyl acetate=2:1) afforded 1.19 g of white crystals.

Provenance & Evidence