Methanol → 5-Chloro-2-methylsulfonylindan-1-one

HRID 896635Notes

Reaction equation

HRID 896635 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH:6](SC)[CH2:5]2.[OH:14][S:15]([O-:18])(=O)=O.[K+].[CH3:20]O>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH:6]([S:15]([CH3:20])(=[O:18])=[O:14])[CH2:5]2

Participants

5

Reactant 3

HCID 887MethanolHCID 516920Potassium bisulfateHCID 99207715-Chloro-2-methylsulfanylindan-1-one

Product 1

HCID 99648205-Chloro-2-methylsulfonylindan-1-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.5 g (2.35 mmol) of 5-chloro-2-methylsulfanylindan-1-one is dissolved in 10 ml of methanol; at 0° C., a solution of 4.33 g (7.05 mmol) of 2KHSO5×KHSO4×K2SO4 in 10 ml of water is added dropwise. The mixture is stirred at room temperature for 5 h; the methanol is distilled off and the aqueous residue is extracted with dichloromethane. The organic phase is separated off, dried over MgSO4, filtered and concentrated under reduced pressure. This gives 0.5 g of 5-chloro-2-methanesulfonylindan-1-one of melting point 197° C.

Workup

  1. distillationthe methanol is distilled off
  2. extractionthe aqueous residue is extracted with dichloromethane
  3. customThe organic phase is separated off
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3f9a196471474bf09cf10c478fdec47b
Source dataset
uspto-grants-2005_07
Patent number
US06919380B2

Reaction notes

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