Diisopropylamine → HCID 22350078, compound

Participants

Reaction Steps

To a solution of (4-methanesulfonyl-phenyl)-acetic acid (2.5 g, 11.7 mmol) in CH2Cl2 (20 mL) was added EDCI (2.46 g, 12.9 mmol) followed by diisopropyl amine (1.2 mL) and DMAP (140 mg, 1.2 mmol). After 18 h at 21° C., the resulting reaction mixture was diluted with a saturated ammonium chloride solution and ethyl acetate. The organic extracts were washed (H2O, brine), dried (MgSO4), filtered and concentrated. Purification by flash chromatography (eluting with hexane/ethyl acetate/THF, 35:60:5) provided the title compound as a white solid.

Provenance & Evidence