HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → C-(4-methanesulfonyl-phenyl)-N,N-dimethyl-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 4-(Methylsulfonyl)benzenemethanesulfonyl chloride | HCID 21962418 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Ammonium Chloride | HCID 25517 | — |
| Product | C-(4-methanesulfonyl-phenyl)-N,N-dimethyl-methanesulfonamide | HCID 22350067 | — |
Reaction Steps
To a solution of (4-methanesulfonyl-phenyl)-methanesulfonyl chloride from Step 2 (1.0 g, 3.7 mmol) in CH2Cl2 (40 mL) was added dimethylamine (0.42 g, 9.3 mmol) dropwise. After 18 h, the resulting reaction mixture was diluted with a saturated ammonium chloride solution and ethyl acetate. The organic extracts were washed (HCl 10%, NaHCO3, brine), dried (MgSO4), filtered, and concentrated to provided the C-(4-methanesulfonyl-phenyl)-N,N-dimethyl-methanesulfonamide compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919353B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-53b37fcf36f64c638d023624da51a376 |
| Source note | uspto-grants-2005_07 |