Dibah → HCID 10229091, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the ester from Step 1, Example 13 (1.0 g, 5 mmol) in CH2Cl2 (25 mL) at −78° C. was added dibal-H (20.1 mL, 12 mmol). The resulting reaction mixture was warmed slowly to 21° C., then quenched with sodium potassium tartrate solution and stirred at 21° C. for 3 h. The reaction mixture was diluted with ethyl acetate. The organic extracts were washed (H2O), (brine), dried (MgSO4), filtered and concentrated. Purification by flash chromatography (eluting with hexane/ethyl acetate, 50:50) provided the title compound as a white foam.

Provenance & Evidence