N-Fluorobenzenesulfonimide → HCID 10189127, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 1 (200 mg, 0.34 mmol) in THF/DMF (1:1, 10 mL) at 0° C. was added potassium tert-butoxide (1M, THF, 0.34 mL, 0.34 mmol) dropwise. After 15 min, N-fluorobenzene sulfonimide (212 mg, 0.73 mmol) was added and the reaction mixture stirred for 2 h at 21° C. The resulting mixture was diluted with a saturated ammonium chloride solution and ethyl acetate. The organic extracts were washed (H2O), (brine), dried (MgSO4), filtered and concentrated. Purification by flash chromatography (eluting with toluene/acetone, 80:20) provided the title compound.

Provenance & Evidence