HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 896689Generated: October 25, 2026
Toluene → 3-[3-(6-Isopropylquinolin-8-yl)-phenyl]-2-[4-(methylsulfonyl)-phenyl]-prop-2-enenitrile
https://huagongshe.com/reaction/896689
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Quinoline | HCID 7047 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-(4-(Methylsulfonyl)phenyl)acetonitrile | HCID 2760950 | — |
| Product | 3-[3-(6-Isopropylquinolin-8-yl)-phenyl]-2-[4-(methylsulfonyl)-phenyl]-prop-2-enenitrile | HCID 69694316 | — |
Reaction Steps
A solution of Quinoline 04 (5 g, 18 mmol), 4-methanesulfonylacetonitrile (3.5 g, 18 mmol) from Step 1 and piperidine (0.1 mL) in toluene (5 mL) was heated at 130° C. After 6 h, the mixture was cooled to 21° C. and purified by flash chromatography (eluting with ethylacetate/hexane, 1:1 to 75:25) to afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06919353B2 |
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| Source dataset | uspto-grants-2005_07 |
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| ORD ID | ord-8451bab0a5a742e684ac51435d4e5a69 |
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| Source note | uspto-grants-2005_07 |
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