HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 896691Generated: October 30, 2026
Tributyltin Chloride → HCID 178438781, compound
https://huagongshe.com/reaction/896691
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tributyltin Chloride | HCID 15096 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 3-[3-(6-Isopropyl-quinolin-8-yl)-phenyl]-2-(4-methanesulfonyl-phenyl)-propionitrile | HCID 10204508 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 178438781 | HCID 178438781 | — |
Reaction Steps
A solution of Example 78 (160 mg, 0.35 mmol), tri-n-butyltin chloride (0.478 mL, 1.76 mmol) and sodium azide (115 mg, 1.76 mmol) in xylene (5 mL) was heated at 150° C. for 18 h. Cooling to 21° C., then purification by flash chromatography (eluting with CH2Cl2/MeOH, NH4OH, 50:5:1) followed by stirring vigorously in ether for 1 h, then filtered, afforded the title compound as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06919353B2 |
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| Source dataset | uspto-grants-2005_07 |
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| ORD ID | ord-1421440d0a4d44bc90c266ad93da7a00 |
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| Source note | uspto-grants-2005_07 |
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