HCID 69693723, compound → HCID 10230591, compound

Participants

Reaction Steps

A solution of 3-{3-[6-(cyano-dimethyl-methyl)-quinolin-8-yl]-phenyl}-N-isopropyl-2-(4-methanesulfonyl-phenyl)-acrylamide from Step 3 (20 mg, 0.038 mmol) in THF (1 mL) containing Pd/C (10%, 9 mg) was stirred under H2 (50 psi) for 18 h. Filtration on celite, evaporation, and purification on HPLC (u-porasil ethyl acetate/hexane, 70:30 to 100:0, over 30 min.) afforded the 3-{3-[6-(cyano-dimethyl-methyl)-quinolin-8-yl]-phenyl}-N-isopropyl-2-(4-methanesulfonyl-phenyl)-propionamide compound as a foam.

Provenance & Evidence