Methyl morpholine oxide → HCID 10141054, compound

Participants

Reaction Steps

A solution of 3-[3-(6-isopropyl-quinolin-8-yl)-phenyl]-2-(4-methylsulfanyl-phenyl)-propionic acid methyl ester from Step 1 (1.05 g, 2.3 mmol), NMO (655 mg, 4.85 mmol) and OsO4 (4%, H2O, 1 mL, 0.16 mmol) in THF (20 mL) was stirred 18 h at 21° C. The resulting reaction mixture was diluted with a sodium metabisulfite solution and ethyl acetate. The organic extracts were washed (H2O, brine), dried (MgSO4), filtered and concentrated. Purification by flash chromatography (eluting with hexane/ethyl acetate, 80:20) provided the 3-[3-(6-isopropyl-quinolin-8-yl)-phenyl]-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester compound.

Provenance & Evidence