Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | HCID 10277075 | HCID 10277075 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 10207923 | HCID 10207923 | — |
Reaction Steps
To a solution of Example 93 (100 mg, 0.21 mmol) in CH2Cl2 (2 mL) was added DMAP (26 mg, 0.21 mmol), EDCI (45 mg, 0.23 mmol), then isopropyl amine (1 mL, 12 mmol). The resulting reaction mixture was stirred 18 h at 21° C., then diluted with a sodium bicarbonate solution and ethyl acetate. The organic extracts were washed (H2O, brine), dried (MgSO4), filtered and concentrated. Purification by flash chromatography (eluting with hexane/ethyl acetate, 80:20 to 20:80) provided the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06919353B2 |
|---|
| Source dataset | uspto-grants-2005_07 |
|---|
| ORD ID | ord-f0c763314cb446c7803187afb7091318 |
|---|
| Source note | uspto-grants-2005_07 |
|---|
