Methyl iodide → HCID 10164037, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 92 (90 mg, 0.185 mmol) in THF/DMF (1:1, 2 mL) at −78° C. was added potassium tert-butoxide (1M, 0.19 mL, 0.19 mmol) dropwise followed by MeI (0,014 mL, 0.22 mmol) after 15 min. The resulting reaction mixture was stirred 18 h at 21° C., then diluted with a saturated ammonium chloride solution and ethyl acetate. The organic extracts were washed (H2O, brine), dried (MgSO4), filtered and concentrated. Purification by flash chromatography (eluting with hexane/ethyl acetate, 50:50) provided the title compound.

Provenance & Evidence