反应详情

A solution of [2-fluoro-5-(6-isopropyl-quinolin-8-yl)-phenyl]-methanol from Step 2 (2.23 g, 7.55 mmol) and MnO2 (13 g, 150 mmol) in CH2Cl2 (70 mL) was stirred at 21° C. for 18 h. The mixture was filtered through a pad of celite and concentrated. Purification by flash chromatography (eluting with hexane/ethyl acetate, 70:30) provided the 2-fluoro-5-(6-isopropylquinolin-8-yl)-benzaldehyde compound.

1. filtrationThe mixture was filtered through a pad of celite and
2. concentrationconcentrated
3. customPurification
4. washby flash chromatography (eluting with hexane/ethyl acetate, 70:30)