Piperidin-4-ol → 4-Piperidinol, 1-(N-((2E)-4-(1-aminocyclobutyl)-1-oxo-2-buten-1-yl)-3-(1,1'-biphenyl)-4-yl-N-methyl-D-alanyl-N-methyl-D-phenylalanyl)-

Participants

Role	Name	HCID	Charge
Reactant	Piperidin-4-ol	HCID 79341	—
Reactant	N-Boc-N-methyl-D-phenylalanine	HCID 7015127	—
Reactant	(2E)-4-(1-{[(tert-butoxy)carbonyl]amino}cyclobutyl)but-2-enoic acid	HCID 10729698	—
Reactant	N-Boc-N-methyl-3-(biphenyl-4-yl)-D-alanine	HCID 20694694	—
Product	4-Piperidinol, 1-(N-((2E)-4-(1-aminocyclobutyl)-1-oxo-2-buten-1-yl)-3-(1,1'-biphenyl)-4-yl-N-methyl-D-alanyl-N-methyl-D-phenylalanyl)-	HCID 11061233	—

Reaction Steps

This compound was prepared as in example 1 but using 4-hydroxypiperidine, (2R)-(N-tert-butoxycarbonyl-N-methylamino)-3-phenylpropionic acid and (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(biphenyl-4-yl)propionic acid and (2E)-4-(1-(tert-butoxycarbonylamino)cyclobutyl)but-2-enoic acid as starting materials.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06919315B1
Source dataset	uspto-grants-2005_07
ORD ID	ord-838d0fe7148741b6841917191442e9e8
Source note	uspto-grants-2005_07