Piperidin-4-ol → (2E)-5-Methyl-5-(methylamino)hex-2-enoic acid N-((1R)-1-{N-[(1R)-1-benzyl-2-(4-hydroxypiperidin-1-yl)-2-oxoethyl]-N-methylcarbamoyl}-2-(biphenyl-4-yl)ethyl)-N-methylamide

Participants

Role	Name	HCID	Charge
Reactant	Piperidin-4-ol	HCID 79341	—
Reactant	N-Boc-N-methyl-D-phenylalanine	HCID 7015127	—
Reactant	(2E)-5-(N-(tert-butoxycarbonyl)-N-methylamino)-5-methylhex-2-enoic acid	HCID 10848750	—
Reactant	N-Boc-N-methyl-3-(biphenyl-4-yl)-D-alanine	HCID 20694694	—
Product	(2E)-5-Methyl-5-(methylamino)hex-2-enoic acid N-((1R)-1-{N-[(1R)-1-benzyl-2-(4-hydroxypiperidin-1-yl)-2-oxoethyl]-N-methylcarbamoyl}-2-(biphenyl-4-yl)ethyl)-N-methylamide	HCID 60017965	—

Reaction Steps

The title compound was prepared as in example 1 but using 4-hydroxypiperidine, (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-phenylpropionic acid and (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(biphenyl-4-yl)propionic acid and (2E)-5-(N-(tert Butoxycarbonyl)-N-methylamino)-5-methylhex-2-enoic acid as starting materials.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06919315B1
Source dataset	uspto-grants-2005_07
ORD ID	ord-f862d0afa6f04963842350d1d2b21407
Source note	uspto-grants-2005_07