Sodium Hydroxide → HCID 131723613, compound

HRID 896981Notes

Reaction equation

HRID 896981 reaction equation
[CH3:1][O:2][P:3]([CH2:7][NH:8][S:9]([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)(=[O:11])=[O:10])(=[O:6])[O:4]C.[OH-].[Na+:18]>>[Na+:18].[CH3:1][O:2][P:3]([CH2:7][NH:8][S:9]([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)(=[O:11])=[O:10])(=[O:4])[O-:6]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 22890942HCID 22890942, compound

Product 1

HCID 131723613HCID 131723613, compound

Procedure

The diester (vii) was treated with sodium hydroxide according to the procedure described in Example 46, step 5, to produce the title compound: 1H NMR (300 MHz, CD3OD) δH 7.65 (dd, J=4.8, 1.2 Hz, 1H), 7.62 (dd, J=3.6, 1.2 Hz, 1H), 7.15 (dd, J=4.8, 3.6 Hz, 1H), 3.55 (d, J=9.3 Hz, 3H), 3.04 (d, J=13.8 Hz, 2H); 31P NMR: (121 MHz, CD3OD) δP 17.60; 13C NMR (75 MHz, CD3OD) δC 141.77, 132.98, 132.90, 128.43, 52.02, 40.11, (d, J=147.2 Hz).

Sources & evidence

ORD record
ord-c21cbee426e343029755b3564888022c
Source dataset
uspto-grants-2005_07
Patent number
US06921756B2

Reaction notes

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