2-Amino-4-chlorobenzoic acid → HCID 22347468, compound

Participants

Reaction Steps

From 1.50 g (7.03 mmol) of 4-allyloxybenzenesulfonyl isocyanate and 1.2 g (7.03 mmol) of 4-chloroanthranilic acid in a similar manner to Preparation Example 5, 1.5 g (yield 53%) of 3-(4-allyloxybenzenesulfonyl)-7-chloro-2,4(1H,3H)-quinazolinedione was obtained. From 500 mg (1.27 mmol) among this, 405 mg of the title compound (yield 90%) was obtained in a similar manner. Property: colorless crystals, melting point: >200° C. (decomposition), PMR (δppm, DMSO-d6): 6.98 (2H, d), 7.11 (1H, s), 7.23 (1H, d), 7.85 (1H, d), 8.00 (2H, d), 11.25 (1H, br).

Provenance & Evidence