259537-23-0 → HCID 22347483, compound

HRID 897017Notes

Reaction equation

HRID 897017 reaction equation
[C:1]([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH2:17])(=[O:16])=[O:15])=[CH:10][C:9]=1[OH:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:19][O:20][C:21](=[O:38])[C:22]1[C:23](=[CH:34][CH:35]=[CH:36][CH:37]=1)[NH:24][C:25](OC1C=CC=CC=1)=[O:26]>>[C:1]([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH:17][C:25]([NH:24][C:23]2[CH:34]=[CH:35][CH:36]=[CH:37][C:22]=2[C:21]([O:20][CH3:19])=[O:38])=[O:26])(=[O:16])=[O:15])=[CH:10][C:9]=1[OH:18])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 904034259537-23-0HCID 22347474HCID 22347474, compound

Product 1

HCID 22347483HCID 22347483, compoundYield 78%

Procedure

From 618 mg (2.26 mmol) of 4-t-butoxycarbonyl-3-hydroxybenzenesulfonamide and 613 mg (2.26 mmol) of 2-N-phenoxycarbonylanthranilic acid methylester in a similar manner to Preparation Example 17, 792 mg (yield 78%) of methyl 2-{[(4-t-butoxycarbonyl-3-hydroxybenzenesulfonylamino)carbonyl]amino}benzoate (property: colorless amorphous, PMR (δppm, CDCl3): 1.60 (9H, s), 3.97 (3H, s), 7.09 (1H, t), 7.49-7.52 (2H, m), 7.65 (1H, d), 7.90 (1H, d), 8.01 (1H, dd), 8.33 (1H, d), 10.98 (1H, s), 11.18 (1H, s)) was obtained.

Sources & evidence

ORD record
ord-4d78d2ba6de14d4992d70c1f1eb087e8
Source dataset
uspto-grants-2005_07
Patent number
US06921766B1

Reaction notes

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